임부 투여 안전성

임부 투여 안전성(pregnancy category, 태아위험도 분류)

 

category

A: 태아에 대한 통제된 연구결과 위험성이 없음

B: 태아에 대해 위험성을 나타낸다는 증거 없음

C: 태아에 대한 위험성을 완전히 배제할 수 없음

D: 태아에 대한 위험성이 증가한다는 증거가 있음

X: 임부에게 투여 금기

 

임부 투여 금기약물

category D

gentamicin/neomycin/amikacin/streptomycin/kanamycin

trimethoprim-sulfamethoxazole

doxycycline/minocycline/tetracycline/tigecycline

fluconazole/voriconazole

primaquine/hydroxychloroquine

phenytoin/fosphenytoin

carbamazepine

midazolam/alprazolam/clonazepam/diazepam

phenobarbital

magnesium sulfate(despite being drug of choice for eclampsia)

lithium

topiramate

pentobarbital

amiodarone

atenolol

lisinopril/captopril/enalapril/benazepril

losartan/valsartan

aspirin(3rd trimester)

edoxaban

warfarin

cortisone/flunisolide

mycophenolate mofetil

penicillamine

methimazole/propylthiouracil/potassium iodide

hydroxyurea

zoledronate

bismuth subsalicylate(3rd trimester only)

cyclophosphamide

ibuprofen(3rd trimester only, otherwise category C)

meloxicam(if >30wks, otherwise category C)

tamoxifen

 

category X

valproate

methotrexate

ribavirin

triazolam

bosenta

aliskiren

emergency contraception(levonorgestrel/ulipristal)

griseofulvin

methylene blue

oxytocin

riociguat

 

한국의약품안전관리원, "임부금기 성분"

https://www.drugsafe.or.kr/iwt/ds/ko/useinfo/EgovDurInfoSerPn.do